Embryo factors play a crucial role in recurrent implantation failure. Quality of embryo varies depending on certain factors including oocyte and sperm quality, parent’s chromosomal anomalies, zona hardening, stage of development and number of transferred embryos. Implantation failure may occur due to any disorders in these factors.
Factors that interfere with implantation include:
· Large fibroids
· Big size endometrial polyp
· Intrauterine adhesions
· Inborn uterine deformities
Estrogen and Progesterone play a major role in developing uterine lining. Both these hormones are watchfully regulated during the IVF procedure.
Hydrosalpinges (collection of fluid in the tubes)
Hydrosalpinges occur in IVF females experiencing tubal disease. IVF procedure is the treatment of choice for women with a loss of tubal function.
Thrombophilia and Immunological Factors
· The major role of the immune system is to defend the body against invading pathogens and infections.
· Uterine Natural Killer (NK) cells get augmented in number in females with RIF. Also, the NK cells present in the blood do not indicate the uterine NK cells presence.
Thrombophilia, which is a disturbance of the blood clotting system, can be associated not only with intermittent pregnancy loss but also with RIF.