Is parental consanguinity associated with low ovarian reserve and a higher rate of aneuploidies?

Abstract

Consanguineous marriage is defined as marriage between second-degree cousins or closer, with high prevalence in the Middle East societies. As consanguine couples are biologically related individual, the increased incidence of autosomal recessive diseases, which are at least ten-fold more prevalent, have been well described. Hence, parental consanguinity has also been associated with reduced ovarian reserve, which have been recently correlated with increase rate of aneuploid embryos.