- Most miscarriages occur randomly when an unusual number of chromosomes reaches the embryo during fertilization.
- The biggest reason for RPL is a genetic abnormality in the fetus.
- Additionally, hormonal disorders (Diabetes and Thyroid problems), uterine problems, and immunological factors may also add to recurring miscarriages.
- Other reasons like smoking, caffeine and alcohol intake, exposure to toxic products, and overweight may also add to the RPL.
Uterine factors may involve:
- Inherited uterine deformities such as the uterine septum, double uterus.
- Presence of large polyps and submucosal fibroids
- Asherman’s syndrome (presence of scar tissue in the uterine cavity)
Screening tests may include:
Genetic Factors (Aneuploidy)
Miscarriage results due to a genetic (chromosomal) anomaly in the embryo.
In couples experiencing frequent miscarriages, one partner carries a chromosome in which a portion is relocated to another chromosome. The process is referred to as translocation. People with translocation typically do not present signs. Some chromosomal deformities can be seen in some of their eggs or sperm. If an embryo receives a high or low amount of genetic material, it may indicate a miscarriage.
Thyroid dysfunction and unregulated blood sugar levels is an indicator of RPL. Furthermore, owing to alterations in the endocrine profile, even PCOS patients carry a greater risk of pregnancy loss.