Is There A Relationship Between Mitochondrial DNA Content And Abortion Rate In Patients Undergoing Single Euploid Frozen Embryo Transfer?

Abstract

The mitochondrial DNA (mtDNA) content of trophectoderm cells is related to the energy supply of the blastocyst, which could affect its ability either to implant in the uterine cavity or not. While it has been demonstrated that euploid blastocysts present a lower mtDNA content as compared to aneuploid blastocysts, there are no data evaluating whether the abortion rate of euploid blastocysts could be associated with their mtDNA content. This information could help maximizing the success rate of single euploid blastocyst transfers in ART by selecting the blastocyst with the highest potential to achieve a live birth.