You are browsing content specific to your location, some treatments may not be available:

Call for an appointment:

+971 2 652 8000

Preimplantation Genetic Testing for Monogenic gene/Single (PGT- M)

Preimplantation genetic testing for a monogenic gene (PGT‐M) is formerly known as Preimplantation genetic diagnosis (PGD).  PGT-M is a diagnostic tool for detecting single-gene disorders in patients with a high risk of passing genetic abnormality to their children. This test helps to reduce the risk of having genetic diseases in children.

Why should PGT- M be done?

This test helps couples in conceiving a healthy pregnancy. The procedure is performed before a female conceives. PGT- M:
•    Examines the DNA of each embryo
•    Recognizes the healthy embryo
•    Assists the physician in deciding which embryo is suitable for transfer

Who should consider PGT-M?

PGT-M is recommended in: 
•    Fertile couples with a family history of a hereditary condition
•    Couples who had a history of severe monogenic disorders (some common examples: Cystic Fibrosis, Spinal Muscular Dystrophies or SMA, Huntington Disease)
•    Women who had a prior pregnancy with a chromosomal deformity

What are the necessities for performing PGT-M?

A genetic disorder results in an altered gene function by an altered DNA sequence (or, mutation).
•    For a PGT-M, a set-up test is important. Each couple has its unique probe which is used to implement the test on embryos
•    Blood samples are taken from the couple or their family members for building the probe.

How and when is PGT-M performed?

Embryo cells are required for the test, thus the biopsy process completes in two steps:
•    Opening of the Zona Pellucida (external shell of the embryo)
•    Removal of the embryo cell(s)
The biopsy is performed on either Day 3 or Day 5.
•    About 6 to 8 cells are present in a Day-3 embryo, so on Day-3, removal of only a single cell is done for the biopsy. 
•    A Day-5 embryo or a Blastocyst has multiple cells, and so numerous cells can be safely removed during the biopsy.
Different approaches for testing the embryo cells include PCR-technique, FISH-technique,  aCGH-technique and NGS. 

Is it safe to perform PGT-M?

It is safe to carry out PGT-M. No birth defects have been observed in IVF babies. The procedure needs to be handled by a skilled embryologist. Normal embryo development can be seen after the embryo biopsy.

Are all the hereditary disorders covered under PGT-M?

No, this test can only examine all possible genetic deformities. PGT-M will test an already known deformity.

Types of treatment related to this article

Preimplantation genetic testing for aneuploidies (PGT‐A), formerly known as preimplantation genetic screening (PGS), is an alternative method to select embryos

Learn More

PGT-SR is a genetic test for detecting inherited chromosomal structural rearrangements in embryos prior to their transfer and enhancing the chance of a

Learn More

IVF means in vitro fertilization.  In vitro means in the laboratory ( outside the body)  and fertilization refers to conception (joining of a woman’s egg and a

Learn More

we are here to help

We are here to help