This procedure includes testing embryos produced via IVF, selecting and transferring the ones with the correct amount of chromosomal material.
• A biopsy of the embryo is taken after it is grown in culture for about five days and reaches the blastocyst developmental stage made up of hundreds of cells.
• The biopsy involves the removal of 5 to 7 cells of the external layer of the embryo, called trophectoderm, without touching the inner cell mass that gives rise to the fetus.
• Analysis of the embryo’s genetic material is carried out using a technique called next generation sequencing (NGS), which interrogates all 46 chromosomes and detects changes in chromosome copy numbers.
• Embryos are cryopreserved following biopsy.
• The presence of unbalanced chromosomal rearrangements may also be determined via the detection of partial/sub-chromosomal gains or losses in genetic material.
• The suitable embryos, based on the PGT-SR results, are thawed and transferred to the patient uterus in a subsequent cycle.