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Is a naturally reduced antim€ullerian hormone at a young age linked to an increased risk of cancer development?

Despite intense research, the pathophysiological mechanisms of premature ovarian aging, leading to reduced ovarian reserve and possibly infertility in young women, are still poorly understood. Well-established risks for reduced ovarian reserve are aggressive ovarian surgery, endometriosis and cytotoxic therapy; however, gene mutations such as the Fragile X syndrome can also cause premature follicle loss and a reduced ovarian reserve.
Hence, in addition to the fact that a reduced ovarian function causing infertility already imposes a heavy psychological burden on the affected patients, data point toward a possible link between gene mutations, impaired DNA repair mechanism, and also an increased risk for the development of cancer. The possible impact of infertility on long-term health and life expectancy is demonstrated by a recently published paper, which describes a 10% increased risk of death in infertile women, with a 47% increased risk of cancer death

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